Gene
vdrb
- ID
- ZDB-GENE-080403-10
- Name
- vitamin D receptor b
- Symbol
- vdrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables nuclear receptor activity. Contributes to DNA-binding transcription factor activity and vitamin D response element binding activity. Acts upstream of or within embryonic heart tube morphogenesis and inner ear development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; heart; intestinal bulb primordium; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017633 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vitamin D-dependent rickets type 2A | Alliance | Rickets, vitamin D-resistant, type IIA | 277440 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR042153 | VDR, DNA-binding domain |
| Family | IPR000324 | Vitamin D receptor |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | VDR, DNA-binding domain | Vitamin D receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1L673
|
422 |
Interactions and Pathways
No data available
Plasmids
No data available