Gene

kif22

ID

ZDB-GENE-080204-34

Name

kinesin family member 22

Symbol

kif22 Nomenclature History

Previous Names

zKIF22 (1)
zgc:171724

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including central nervous system development; somitogenesis; and thigmotaxis. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in brain. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Blaker-Lee et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif22 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spondyloepimetaphyseal dysplasia with joint laxity type 2	Alliance	Spondyloepimetaphyseal dysplasia with joint laxity, type 2	603546

Associated With kif22 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR010994	RuvA domain 2-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily