Gene

cishb

ID

ZDB-GENE-080204-120

Name

cytokine inducible SH2-containing protein b

Symbol

cishb Nomenclature History

Previous Names

socs8
zgc:175109

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable cytokine receptor binding activity. Predicted to be involved in cytokine-mediated signaling pathway and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within intracellular signal transduction and negative regulation of signal transduction. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cishb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Bacteremia, susceptibility to}	614383
		{Malaria, susceptibility to}	611162
		{Tuberculosis, susceptibility to}	607948

Associated With cishb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR001496	SOCS box domain
Domain	IPR035887	CIS, SH2 domain
Homologous_superfamily	IPR036036	SOCS box-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily