Gene

il6r

ID

ZDB-GENE-080107-7

Name

interleukin 6 receptor

Symbol

il6r Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within positive regulation of neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be part of CRLF-CLCF1 complex and receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including epidermis; immune system; lateral line; liver; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il6r Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections	618944
		[Interleukin 6, serum level of, QTL]	614752
		[Interleukin-6 receptor, soluble, serum level of, QTL]	614689

Associated With il6r Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site
Domain	IPR003961	Fibronectin type III
Family	IPR050379	Type I Cytokine Receptor
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Long hematopoietin receptor, soluble alpha chain, conserved site	Type I Cytokine Receptor
UniProtKB:A0A7S9AT90 InterPro
UniProtKB:A0A7S9ATA7 InterPro
UniProtKB:A0A8M1PAC4 InterPro	604

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	il6r-201 (1) Ensembl	Ensembl		2,555 nt	Select Tool ZFIN BLAST
mRNA	il6r-202 (1) Ensembl	Ensembl		4,005 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations