Gene
il6st
- ID
- ZDB-GENE-080104-6
- Name
- interleukin 6 cytokine family signal transduce
- Symbol
- il6st Nomenclature History
- Previous Names
-
- gp130 (1)
- sb:eu844
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have cytokine binding activity and cytokine receptor activity. Involved in positive regulation of axon regeneration. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary cutaneous amyloidosis. Is expressed in several structures, including epidermis; immune system; liver; muscle; and sensory system. Orthologous to several human genes including IL6ST (interleukin 6 signal transducer).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu844 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyper IgE recurrent infection syndrome 4 | Alliance | Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections | 618523 |
| Hyper-IgE syndrome 4A, autosomal dominant, with recurrent infections | 619752 | ||
| Stuve-Wiedemann syndrome 2 | 619751 | ||
| ?Immunodeficiency 94 with autoinflammation and dysmorphic facies | 619750 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Type I Cytokine Receptor |
|---|---|---|---|---|---|
|
UniProtKB:F1RCZ2
|
859 | ||||
|
UniProtKB:A8WH79
|
866 |
Interactions and Pathways
No data available
Plasmids
No data available