Gene

plcd1a

ID

ZDB-GENE-071004-78

Name

phospholipase C, delta 1a

Symbol

plcd1a Nomenclature History

Previous Names

DrPLC-delta 1A (1)
zgc:165641

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Ma et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Ma et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plcd1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nonsyndromic congenital nail disorder 3	Alliance	Nail disorder, nonsyndromic congenital, 3, (leukonychia)	151600

Associated With plcd1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR000008	C2 domain
Domain	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
Domain	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002048	EF-hand domain
Domain	IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain
Domain	IPR028391	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain
Domain	IPR046975	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain
Family	IPR001192	Phosphoinositide phospholipase C family
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain	C2 domain	C2 domain superfamily	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	PH-like domain superfamily	Phosphatidylinositol-specific phospholipase C, X domain	Phosphoinositide phospholipase C family	Phosphoinositide-specific phospholipase C, EF-hand-like domain	Phospholipase C, phosphatidylinositol-specific, Y domain	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Pleckstrin homology domain
UniProtKB:A0A0R4IGD7 InterPro	752
UniProtKB:A7MD68 InterPro	775

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plcd1a-201 (1) Ensembl	Ensembl	2,776 nt	Select Tool ZFIN BLAST
mRNA	plcd1a-202 (1) Ensembl	Ensembl	2,962 nt	Select Tool ZFIN BLAST
mRNA	plcd1a-203 (1) Ensembl	Ensembl	532 nt	Select Tool ZFIN BLAST
mRNA	plcd1a-204 (1) Ensembl	Ensembl	5,070 nt	Select Tool ZFIN BLAST
mRNA	plcd1a-205 (1) Ensembl	Ensembl	5,157 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations