Gene

scn3b

ID

ZDB-GENE-070920-2

Name

sodium channel, voltage-gated, type III, beta

Symbol

scn3b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have ion channel binding activity and sodium channel inhibitor activity. Predicted to be involved in regulation of heart rate by cardiac conduction; regulation of sodium ion transmembrane transporter activity; and ventricular cardiac muscle cell action potential. Predicted to localize to voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Is expressed in atrium; brain; cardiac ventricle; and eye. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scn3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Brugada syndrome 7	Alliance	Atrial fibrillation, familial, 16	613120
Brugada syndrome 7	Alliance	Brugada syndrome 7	613120

Associated With scn3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Family	IPR027098	Sodium channel subunit beta-1/beta-3
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily