Gene
nfatc4
- ID
- ZDB-GENE-070912-659
- Name
- nuclear factor of activated T cells 4
- Symbol
- nfatc4 Nomenclature History
- Previous Names
-
- si:dkeyp-66d1.4 (1)
- si:dkeyp-66d1.5
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in calcineurin-NFAT signaling cascade; cytokine production; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol; nucleus; and transcription regulator complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Pistocchi et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR002909 | IPT domain |
Domain | IPR011539 | Rel homology domain, DNA-binding domain |
Domain | IPR032397 | Rel homology dimerisation domain |
Family | IPR008366 | Nuclear factor of activated T cells (NFAT) |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Nuclear factor of activated T cells (NFAT) | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7F059
|
865 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
nfatc4-201
(1)
|
Ensembl | 3,769 nt | ||
mRNA |
nfatc4-202
(1)
|
Ensembl | 944 nt | ||
ncRNA |
nfatc4-003
(1)
|
Ensembl | 861 nt |
Interactions and Pathways
No data available
Plasmids
No data available