Gene

zeb2a

ID
ZDB-GENE-070912-553
Name
zinc finger E-box binding homeobox 2a
Symbol
zeb2a Nomenclature History
Previous Names
  • zeb2
  • sb:eu412
  • si:dkey-52o2.2
  • sip1a (1)
  • Smad-interacting protein-1a (1)
  • wu:fc92g08
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including chordate embryonic development; convergent extension; and negative regulation of fibroblast growth factor receptor signaling pathway. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Is expressed in several structures, including head; nervous system; neural plate; neuroectoderm; and tail bud. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zeb2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mowat-Wilson syndrome Alliance Mowat-Wilson syndrome 235730
Associated With zeb2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR008598 Drought induced 19 protein type, zinc-binding domain
Domain IPR013087 Zinc finger C2H2-type
Family IPR051574 Zinc finger E-box-binding homeobox
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Drought induced 19 protein type, zinc-binding domain Zinc finger C2H2 superfamily Zinc finger C2H2-type Zinc finger E-box-binding homeobox
UniProtKB:B5DE38 1175
UniProtKB:F1QY45 1218
UniProtKB:A0A8M9Q4G0 1095
UniProtKB:B0LVE9 1201
UniProtKB:A0A8M2BFJ5 1192
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA zeb2a-201 (1) Ensembl 4,058 nt
mRNA zeb2a-202 (1) Ensembl 1,351 nt
mRNA zeb2a-203 (1) Ensembl 448 nt
mRNA zeb2a-204 (1) Ensembl 859 nt
mRNA zeb2a-206 (1) Ensembl 4,250 nt
mRNA zeb2a-207 (1) Ensembl 3,606 nt
mRNA zeb2a-208 (1) Ensembl 5,237 nt
ncRNA zeb2a-004 (1) Ensembl 940 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations