Gene
htr2aa
- ID
- ZDB-GENE-070912-500
- Name
- 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
- Symbol
- htr2aa Nomenclature History
- Previous Names
-
- htr2a
- si:dkey-284e7.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including axon; caveola; and presynapse. Predicted to be active in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| melancholic depression | Alliance | {Major depressive disorder, response to citalopram therapy in} | 608516 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
| {Obsessive-compulsive disorder, susceptibility to} | 164230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
|
UniProtKB:A0A8N7TD42
|
491 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htr2aa-201
(1)
|
Ensembl | 1,208 nt |
Interactions and Pathways
No data available
Plasmids
No data available