Gene

zeb1a

ID
ZDB-GENE-070912-124
Name
zinc finger E-box binding homeobox 1a
Symbol
zeb1a Nomenclature History
Previous Names
  • si:ch211-159p3.1
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and metal ion binding activity. Involved in regulation of cell-cell adhesion involved in gastrulation and smooth muscle tissue development. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Is expressed in hypoblast and neural plate. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Gays et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zeb1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 6 613270
posterior polymorphous corneal dystrophy 3 Alliance Corneal dystrophy, posterior polymorphous, 3 609141
Associated With zeb1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Family IPR051574 Zinc finger E-box-binding homeobox
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type Zinc finger E-box-binding homeobox
UniProtKB:F1QMZ5 1190
UniProtKB:F1QBD3 1176
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA zeb1a-201 (1) Ensembl 3,933 nt
mRNA zeb1a-203 (1) Ensembl 761 nt
mRNA zeb1a-204 (1) Ensembl 3,650 nt
mRNA zeb1a-205 (1) Ensembl 3,855 nt
ncRNA zeb1a-002 (1) Ensembl 568 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations