Gene
chrnb2
- ID
- ZDB-GENE-070821-3
- Name
- cholinergic receptor, nicotinic, beta 2
- Symbol
- chrnb2 Nomenclature History
- Previous Names
-
- chrnb2
- chrnb2b (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to contribute to acetylcholine binding activity and acetylcholine receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; regulation of membrane potential; and response to nicotine. Predicted to localize to acetylcholine-gated channel complex; neuron projection; and synapse. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nocturnal frontal lobe epilepsy 3 | Alliance | Epilepsy, nocturnal frontal lobe, 3 | 605375 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR002394 | Nicotinic acetylcholine receptor |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
| Homologous_superfamily | IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| Homologous_superfamily | IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
| Homologous_superfamily | IPR038050 | Neuronal acetylcholine receptor |
Domain Details Per Protein
| Protein | Length | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily | Nicotinic acetylcholine receptor |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F4S7
|
543 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chrnb2-201
(1)
|
Ensembl | 6,596 nt | ||
| mRNA |
chrnb2-203
(1)
|
Ensembl | 6,862 nt | ||
| mRNA |
chrnb2-204
(1)
|
Ensembl | 6,551 nt | ||
| mRNA |
chrnb2b-202
(1)
|
Ensembl | 1,685 nt |
Interactions and Pathways
No data available
Plasmids
No data available