Gene
tars2
- ID
- ZDB-GENE-070815-3
- Name
- threonyl-tRNA synthetase 2, mitochondrial
- Symbol
- tars2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable threonine-tRNA ligase activity. Acts upstream of or within cerebellum development and skeletal muscle fiber development. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including early embryonic cell; head; heart; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
-
- Alliance (1)
- Gene:100333765 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Accogli et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Accogli et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 21 | Alliance | Combined oxidative phosphorylation deficiency 21 | 615918 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR004095 | TGS |
| Domain | IPR004154 | Anticodon-binding |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR033728 | Threonine-tRNA ligase catalytic core domain |
| Domain | IPR047246 | Threonine-tRNA ligase, class IIa, anticodon-binding domain |
| Family | IPR002320 | Threonine-tRNA ligase, class IIa |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR018163 | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
| Homologous_superfamily | IPR036621 | Anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Anticodon-binding | Anticodon-binding domain superfamily | Beta-grasp domain superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | TGS | Threonine-tRNA ligase catalytic core domain | Threonine-tRNA ligase, class IIa | Threonine-tRNA ligase, class IIa, anticodon-binding domain | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PJQ9
|
687 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance