Gene

adamts5

ID

ZDB-GENE-070814-2

Name

ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

Symbol

adamts5 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Acts upstream of or within heart development. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamts5 Human Ortholog

No data available

Associated With adamts5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR006586	ADAM, cysteine-rich domain
Domain	IPR010294	ADAMTS/ADAMTS-like, Spacer 1
Domain	IPR041645	ADAMTS, cysteine-rich domain 2
Domain	IPR045371	ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family	IPR013273	ADAMTS/ADAMTS-like
Family	IPR013276	Peptidase M12B, ADAM-TS5
Family	IPR050439	ADAMTS and ADAMTS-like
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Additional Resources	Length	ADAM, cysteine-rich domain	ADAMTS/ADAMTS-like	ADAMTS/ADAMTS-like, cysteine-rich domain 3	ADAMTS/ADAMTS-like, Spacer 1	ADAMTS and ADAMTS-like	ADAMTS, cysteine-rich domain 2	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, ADAM-TS5	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:G3G3J8	InterPro	937

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	adamts5-201 (1) Ensembl	Ensembl		2,814 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations