Gene

ralgps1

ID

ZDB-GENE-070720-16

Name

Ral GEF with PH domain and SH3 binding motif 1

Symbol

ralgps1 Nomenclature History

Previous Names

zgc:165535

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Orthologous to human RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ebarasi et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ralgps1 Human Ortholog

No data available

Associated With ralgps1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily