Gene
alx4a
- ID
- ZDB-GENE-070712-3
- Name
- ALX homeobox 4a
- Symbol
- alx4a Nomenclature History
- Previous Names
-
- alx4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in multicellular organism development and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Is expressed in cranial neural crest; head; head mesenchyme; and pectoral fin bud. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Jang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
| parietal foramina | Alliance | Parietal foramina 2 | 609597 |
| {Craniosynostosis 5, susceptibility to} | 615529 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired Homeobox Transcription Factors |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FGP3
|
368 |
Interactions and Pathways
No data available
Plasmids
No data available