Gene
hscb
- ID
- ZDB-GENE-070705-97
- Name
- HscB mitochondrial iron-sulfur cluster cochaperone
- Symbol
- hscb Nomenclature History
- Previous Names
-
- si:ch211-207k7.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ATPase activator activity and chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to act upstream of or within protein complex oligomerization and protein maturation by iron-sulfur cluster transfer. Predicted to be active in mitochondrion. Is expressed in blood island. Used to study sideroblastic anemia. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Crispin et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Crispin et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| sideroblastic anemia 5 | Alliance | ?Anemia, sideroblastic, 5 | 619523 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| sideroblastic anemia | WT + MO1-hscb | standard conditions | Crispin et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chaperone J-domain superfamily | Co-chaperone Hsc20 | Co-chaperone HscB, C-terminal oligomerisation domain | DnaJ domain | HscB, C-terminal domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:B0V1J6
|
267 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-207k7.4-201
(1)
|
Ensembl | 963 nt |
Interactions and Pathways
No data available
Plasmids
No data available