Gene
kremen1
- ID
- ZDB-GENE-070705-262
- Name
- kringle containing transmembrane protein 1
- Symbol
- kremen1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and transferase activity. Involved in angiogenesis; lateral line development; and liver development. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Is expressed in lens; midbrain hindbrain boundary; otic vesicle; posterior lateral line primordium; and ventral fin fold. Orthologous to several human genes including KREMEN1 (kringle containing transmembrane protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia 13 | Alliance | Ectodermal dysplasia 13, hair/tooth type | 617392 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000859 | CUB domain |
| Domain | IPR002889 | Carbohydrate-binding WSC |
| Family | IPR051073 | ZNRF3/Arkadia E3 ubiquitin-protein ligases |
| Family | IPR051836 | Kremen receptor |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
Domain Details Per Protein
| Protein | Length | Carbohydrate-binding WSC | CUB domain | Kremen receptor | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Spermadhesin, CUB domain superfamily | ZNRF3/Arkadia E3 ubiquitin-protein ligases |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ARY7
|
451 | |||||||||
|
UniProtKB:B0BLV6
|
465 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kremen1-201
(1)
|
Ensembl | 2,365 nt | ||
| mRNA |
kremen1-203
(1)
|
Ensembl | 867 nt | ||
| ncRNA |
kremen1-002
(1)
|
Ensembl | 673 nt |
Interactions and Pathways
No data available
Plasmids
No data available