Gene
apoba
- ID
- ZDB-GENE-070702-4
- Name
- apolipoprotein Ba
- Symbol
- apoba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have lipid transporter activity. Predicted to be involved in cholesterol transport and triglyceride mobilization. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Is expressed in heart; liver; and yolk syncytial layer. Orthologous to human APOB (apolipoprotein B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911942 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypobetalipoproteinemia 1 | Alliance | Hypobetalipoproteinemia | 615558 |
| Hypercholesterolemia, familial, 2 | 144010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR009454 | Lipid transport, open beta-sheet |
| Domain | IPR015255 | Vitellinogen, open beta-sheet |
| Family | IPR052418 | Apolipoprotein B |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
| Homologous_superfamily | IPR015819 | Lipid transport protein, beta-sheet shell |
Domain Details Per Protein
| Protein | Length | Apolipoprotein B | Lipid transport, open beta-sheet | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, open beta-sheet | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T7N7
|
4418 |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance