Gene

lyst

ID

ZDB-GENE-070702-1

Name

lysosomal trafficking regulator

Symbol

lyst Nomenclature History

Previous Names

si:ch211-30i2.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to be involved in lysosome organization. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Kim et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lyst Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Chediak-Higashi syndrome	Alliance	Chediak-Higashi syndrome	214500

Associated With lyst Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR000409	BEACH domain
Domain	IPR023362	PH-BEACH domain
Family	IPR050865	BEACH Domain-Containing
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036372	BEACH domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	BEACH domain	BEACH Domain-Containing	BEACH domain superfamily	PH-BEACH domain	PH-like domain superfamily	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M6Z3Z4 InterPro	3826
UniProtKB:A0A8M6Z2E9 InterPro	3886
UniProtKB:A0A8M9PU84 InterPro	3832
UniProtKB:A0A8M3AZH9 InterPro	3832

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	lyst-201 (1) Ensembl	Ensembl		8,001 nt	Select Tool ZFIN BLAST
mRNA	lyst-202 (1) Ensembl	Ensembl		7,983 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations