Gene

igfbp5a

ID

ZDB-GENE-070620-8

Name

insulin-like growth factor binding protein 5a

Symbol

igfbp5a Nomenclature History

Previous Names

igfbp5b
zgc:165472

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to localize to extracellular space. Is expressed in several structures, including extension; gill filament; male organism; otic vesicle; and yolk syncytial layer. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Liu et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igfbp5a Human Ortholog

No data available

Associated With igfbp5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR000867	Insulin-like growth factor-binding protein, IGFBP
Family	IPR012213	Insulin-like growth factor binding protein 5
Family	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily