Gene

ptprdb

ID

ZDB-GENE-070615-38

Name

protein tyrosine phosphatase receptor type Db

Symbol

ptprdb Nomenclature History

Previous Names

ptprd
zgc:165626

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in nervous system development; signal transduction; and synaptic membrane adhesion. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in plasma membrane. Is expressed in Rohon-Beard neurons; lateral line ganglion; olfactory placode; and trigeminal ganglion. Human ortholog(s) of this gene implicated in coronary artery disease; diabetes mellitus; hypertension; and type 2 diabetes mellitus. Orthologous to human PTPRD (protein tyrosine phosphatase receptor type D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptprdb Human Ortholog

No data available

Associated With ptprdb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR050713	Receptor-type Tyrosine-protein Phosphatases/Ushers
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PV64	InterPro	1942
UniProtKB:A0A8M9PHQ2	InterPro	1949
UniProtKB:A5PLI0	InterPro	205
UniProtKB:A0A8M9PHN2	InterPro	1951
UniProtKB:A0A8M3AYU7	InterPro	1505
UniProtKB:A0A8M9PI44	InterPro	1517
UniProtKB:A0A8M9Q6X8	InterPro	1940
UniProtKB:A0A8M9QBW3	InterPro	1946
UniProtKB:A0A8M9PHF1	InterPro	1955
UniProtKB:A0A0R4IXV2	InterPro	1515
UniProtKB:A0A8M9PVC0	InterPro	1523
UniProtKB:A0A8M3B7T2	InterPro	1512
UniProtKB:A0A8M9PVJ4	InterPro	1513
UniProtKB:A0A8M3B7T6	InterPro	1509
UniProtKB:A0A8M6YWY1	InterPro	1947
UniProtKB:A0A8M6YXY1	InterPro	1938
UniProtKB:B8A5J5	InterPro	1934
UniProtKB:A0A8M9Q0S4	InterPro	1954
UniProtKB:A0A8M9PV18	InterPro	1948
UniProtKB:A0A8M9Q0T4	InterPro	1952

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptprdb-201 (1) Ensembl	Ensembl	1,140 nt	Select Tool ZFIN BLAST
mRNA	ptprdb-202 (1) Ensembl	Ensembl	6,806 nt	Select Tool ZFIN BLAST
mRNA	ptprdb-203 (1) Ensembl	Ensembl	957 nt	Select Tool ZFIN BLAST
mRNA	ptprdb-204 (1) Ensembl	Ensembl	5,805 nt	Select Tool ZFIN BLAST
mRNA	ptprdb-205 (1) Ensembl	Ensembl	4,548 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:37112

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations