Gene
f2rl1.2
- ID
- ZDB-GENE-070615-24
- Name
- coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2
- Symbol
- f2rl1.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Exhibits proteinase activated receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Is expressed in digestive system; notochord; otic vesicle; and pronephric duct. Orthologous to human F2RL1 (F2R like trypsin receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schepis et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Protease-activated receptor | Protease-activated receptor 2 |
|---|---|---|---|---|---|
|
UniProtKB:I3IRY7
|
390 | ||||
|
UniProtKB:A5PLC2
|
389 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
f2rl1.2-201
(1)
|
Ensembl | 1,486 nt | ||
| mRNA |
f2rl1.2-202
(1)
|
Ensembl | 1,493 nt |
Interactions and Pathways
No data available
Plasmids
No data available