Gene
ngfrb
- ID
- ZDB-GENE-070606-2
- Name
- nerve growth factor receptor b
- Symbol
- ngfrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have coreceptor activity; death receptor activity; and nerve growth factor binding activity. Involved in posterior lateral line neuromast deposition. Predicted to localize to cell surface and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Is expressed in cranial ganglion; posterior lateral line primordium; and trigeminal ganglion. Orthologous to human NGFR (nerve growth factor receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000488 | Death domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR034046 | Tumor necrosis factor receptor 16, N-terminal |
| Domain | IPR041448 | Tumor necrosis factor receptor member 16, transmembrane domain |
| Family | IPR022325 | Tumour necrosis factor receptor 16 |
| Family | IPR052302 | Neurotrophin receptor-related death domain-containing protein |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Death domain | Death-like domain superfamily | Neurotrophin receptor-related death domain-containing protein | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 16, N-terminal | Tumor necrosis factor receptor member 16, transmembrane domain | Tumour necrosis factor receptor 16 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E2DGP8
|
431 |
Interactions and Pathways
No data available
Plasmids
No data available