Gene

ngfrb

ID

ZDB-GENE-070606-2

Name

nerve growth factor receptor b

Symbol

ngfrb Nomenclature History

Previous Names

NGFRa (1)
ngfrl
p75 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable coreceptor activity; death receptor activity; and nerve growth factor binding activity. Acts upstream of or within kidney development and posterior lateral line neuromast deposition. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in brain; cranial ganglion; posterior lateral line primordium; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ngfrb Human Ortholog

No data available

Associated With ngfrb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000488	Death domain
Domain	IPR001368	TNFR/NGFR cysteine-rich region
Domain	IPR034046	Tumor necrosis factor receptor 16, N-terminal
Domain	IPR041448	Tumor necrosis factor receptor member 16, transmembrane domain
Family	IPR022325	Tumour necrosis factor receptor 16
Family	IPR052302	Neurotrophin receptor-related death domain-containing protein
Homologous_superfamily	IPR011029	Death-like domain superfamily