Gene

ccnd2a

ID

ZDB-GENE-070424-30

Name

cyclin D2, a

Symbol

ccnd2a Nomenclature History

Previous Names

ccnd2
gb:bi671621
zgc:162280

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in pharyngeal arch and testis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; hepatitis B; and liver cancer (multiple). Orthologous to human CCND2 (cyclin D2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ccnd2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	615938

Associated With ccnd2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR048258	Cyclins, cyclin-box
Domain	IPR004367	Cyclin, C-terminal domain
Domain	IPR006671	Cyclin, N-terminal
Domain	IPR013763	Cyclin-like domain
Family	IPR039361	Cyclin
Family	IPR046965	Cyclin A/B-like
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Length	Cyclin	Cyclin A/B-like	Cyclin, C-terminal domain	Cyclin-like domain	Cyclin-like superfamily	Cyclin, N-terminal	Cyclins, cyclin-box
UniProtKB:A3KNN7 InterPro	298
UniProtKB:A0A8M2BLM1 InterPro	218

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ccnd2a-201 (1) Ensembl	Ensembl	1,293 nt	Select Tool ZFIN BLAST
mRNA	ccnd2a-203 (1) Ensembl	Ensembl	287 nt	Select Tool ZFIN BLAST
mRNA	ccnd2a-204 (1) Ensembl	Ensembl	476 nt	Select Tool ZFIN BLAST
mRNA	ccnd2a-205 (1) Ensembl	Ensembl	727 nt	Select Tool ZFIN BLAST
ncRNA	ccnd2a-002 (1) Ensembl	Ensembl	414 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations