Gene

nlrp3

ID

ZDB-GENE-070424-110

Name

NLR family pyrin domain containing 3

Symbol

nlrp3 Nomenclature History

Previous Names

si:ch211-114l13.10
si:dkey-156m2.3

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Involved in NLRP3 inflammasome complex assembly and positive regulation of pyroptosis. Acts upstream of or within pyroptosis. Part of NLRP3 inflammasome complex and enzyme activator complex. Is expressed in gill and intestine. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlrp3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 34	Alliance	Deafness, autosomal dominant 34, with or without inflammation	617772
CINCA Syndrome	Alliance	CINCA syndrome	607115
familial cold autoinflammatory syndrome 1	Alliance	Familial cold inflammatory syndrome 1	120100
Muckle-Wells syndrome	Alliance	Muckle-Wells syndrome	191900
		Keratoendothelitis fugax hereditaria	148200

Associated With nlrp3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001870	B30.2/SPRY domain
Domain	IPR003877	SPRY domain
Domain	IPR003879	Butyrophylin-like, SPRY domain
Domain	IPR004020	DAPIN domain
Domain	IPR006574	SPRY-associated
Domain	IPR007111	NACHT nucleoside triphosphatase
Domain	IPR029495	NACHT-associated domain
Domain	IPR041075	NOD1/2, winged helix domain
Domain	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2
Family	IPR051261	NOD-like receptor (NLR)
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR043136	B30.2/SPRY domain superfamily
Repeat	IPR001611	Leucine-rich repeat

Domain Details Per Protein

Protein	Length	B30.2/SPRY domain	B30.2/SPRY domain superfamily	Butyrophylin-like, SPRY domain	Concanavalin A-like lectin/glucanase domain superfamily	DAPIN domain	Death-like domain superfamily	Leucine-rich repeat	Leucine-rich repeat domain superfamily	NACHT-associated domain	NACHT, LRR and PYD domains-containing protein, helical domain HD2	NACHT nucleoside triphosphatase	NOD1/2, winged helix domain	NOD-like receptor (NLR)	P-loop containing nucleoside triphosphate hydrolase	SPRY-associated	SPRY domain
UniProtKB:A0A8M6YY09 InterPro	1121

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:dkey-156m2.3-201 (1) Ensembl	Ensembl		6,595 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations