Gene

rfc1

ID

ZDB-GENE-070410-99

Name

replication factor C (activator 1) 1

Symbol

rfc1 Nomenclature History

Previous Names

si:dkey-170e5.1
zgc:162875 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rfc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	614575

Associated With rfc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001357	BRCT domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR013725	DNA replication factor RFC1, C-terminal
Domain	IPR047854	Replication factor C, lid domain
Family	IPR012178	Replication factor C subunit 1
Homologous_superfamily	IPR008921	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036420	BRCT domain superfamily

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	ATPase, AAA-type, core	BRCT domain	BRCT domain superfamily	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal	DNA replication factor RFC1, C-terminal	P-loop containing nucleoside triphosphate hydrolase	Replication factor C, lid domain	Replication factor C subunit 1
UniProtKB:F1Q5P6 InterPro	1147

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rfc1-201 (1) Ensembl	Ensembl	4,162 nt	Select Tool ZFIN BLAST
mRNA	rfc1-203 (1) Ensembl	Ensembl	660 nt	Select Tool ZFIN BLAST
mRNA	rfc1-204 (1) Ensembl	Ensembl	2,981 nt	Select Tool ZFIN BLAST
ncRNA	rfc1-002 (1) Ensembl	Ensembl	314 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations