Gene
nme9
- ID
- ZDB-GENE-070410-39
- Name
- NME/NM23 family member 9
- Symbol
- nme9 Nomenclature History
- Previous Names
-
- nme8
- NM23-Z8 (1)
- txndc3
- txndc6
- zgc:162216
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable nucleoside diphosphate kinase activity. Predicted to act upstream of or within CTP biosynthetic process; GTP biosynthetic process; and UTP biosynthetic process. Is expressed in male organism. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to several human genes including NME9 (NME/NM23 family member 9).
- Genome Resources
- Note
-
Desvignes et al. (2008) originally identified this gene as nme8, an ortholog to mammalian NME8, based, in part, on the mis-identified X. tropicalis gene/protein NP_001121456. Updated genome information indicates that nme8 was lost in zebrafish (and some other teleosts), suggesting this gene is actually orthologous to mammalian NME9
- Comparative Information
-
- All Expression Data
- 1 figure from Desvignes et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017937 | Thioredoxin, conserved site |
| Domain | IPR013766 | Thioredoxin domain |
| Domain | IPR034907 | Nucleoside diphosphate kinase-like domain |
| Family | IPR001564 | Nucleoside diphosphate kinase |
| Family | IPR051766 | Thioredoxin domain-containing protein |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036850 | Nucleoside diphosphate kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nucleoside diphosphate kinase | Nucleoside diphosphate kinase-like domain | Nucleoside diphosphate kinase-like domain superfamily | Thioredoxin, conserved site | Thioredoxin domain | Thioredoxin domain-containing protein | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QAK2
|
661 | |||||||
|
UniProtKB:A0A8M9Q4G2
|
665 | |||||||
|
UniProtKB:A0A8M9QJH0
|
660 | |||||||
|
UniProtKB:A4IG45
|
531 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available