Gene
sgpl1
- ID
- ZDB-GENE-070410-24
- Name
- sphingosine-1-phosphate lyase 1
- Symbol
- sgpl1 Nomenclature History
- Previous Names
-
- spl (1)
- zgc:162153
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have sphinganine-1-phosphate aldolase activity. Predicted to be involved in ameboidal-type cell migration and sphingolipid catabolic process. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk syncytial layer. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7163588 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 14 | Alliance | RENI syndrome | 617575 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
| Family | IPR050477 | Group II Amino Acid Decarboxylases |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Group II Amino Acid Decarboxylases | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A4QNU7
|
572 | |||||
|
UniProtKB:A0A2R8Q3N8
|
574 |
Interactions and Pathways
No data available
Plasmids
No data available