Gene

mlycd

ID

ZDB-GENE-070410-120

Name

malonyl-CoA decarboxylase

Symbol

mlycd Nomenclature History

Previous Names

zgc:162977

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable malonyl-CoA decarboxylase activity. Predicted to be involved in acetyl-CoA biosynthetic process; malonyl-CoA catabolic process; and positive regulation of fatty acid oxidation. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix and peroxisomal matrix. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mlycd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Malonyl-CoA decarboxylase deficiency	248360

Associated With mlycd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007956	Malonyl-CoA decarboxylase, C-terminal
Domain	IPR035372	Malonyl-CoA decarboxylase, N-terminal
Family	IPR038917	Malonyl-CoA decarboxylase
Homologous_superfamily	IPR038351	Malonyl-CoA decarboxylase, N-terminal domain superfamily
Homologous_superfamily	IPR042303	Malonyl-CoA decarboxylase, C-terminal catalytic domain superfamily