Gene

nrxn1a

ID

ZDB-GENE-070206-1

Name

neurexin 1a

Symbol

nrxn1a Nomenclature History

Previous Names

nrxn1aa
nrxn1ab

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Involved in sprouting angiogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Orthologous to human NRXN1 (neurexin 1).

Genome Resources

Note

nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rissone et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrxn1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Pitt-Hopkins-like syndrome 2	Alliance	Pitt-Hopkins-like syndrome 2	614325
		{Schizophrenia, susceptibility to, 17}	614332

Associated With nrxn1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR003585	Neurexin/syndecan/glycophorin C
Domain	IPR027789	Syndecan/Neurexin domain
Family	IPR050372	Neurexin-related cell adhesion and synaptic protein
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	Laminin G domain	Neurexin-related cell adhesion and synaptic protein	Neurexin/syndecan/glycophorin C	Syndecan/Neurexin domain
UniProtKB:A0A2R8QKE7 InterPro	1481
UniProtKB:A1XQX1 InterPro	449
UniProtKB:A0A8M3B4L1 InterPro	1491
UniProtKB:A0A8M3BE54 InterPro	1488
UniProtKB:A0A8M3AYC5 InterPro	1489
UniProtKB:A0A8M3AYD0 InterPro	1454
UniProtKB:A0A8M3B7E0 InterPro	1492
UniProtKB:A0A8M9QIT8 InterPro	1445
UniProtKB:A0A8M3BE57 InterPro	1451
UniProtKB:A0A8M2B276 InterPro	1488
UniProtKB:A0A8M9QED3 InterPro	1475
UniProtKB:A0A8M3B7E5 InterPro	1467
UniProtKB:A0A8M9Q8I0 InterPro	1477
UniProtKB:A0A8M9QIT3 InterPro	1487
UniProtKB:A0A8M3B4L5 InterPro	1464
UniProtKB:A0A8M3B7D6 InterPro	1497
UniProtKB:A1XQX0 InterPro	1491
UniProtKB:A0A8M3B4K7 InterPro	1496
UniProtKB:A0A140TAU1 InterPro	1484
UniProtKB:A0A8M9QML2 InterPro	1414
UniProtKB:A0A8M3AY99 InterPro	1493
UniProtKB:A0A8M3BE52 InterPro	1493
UniProtKB:A0A8M9QIU1 InterPro	1422
UniProtKB:A0A8M9QED6 InterPro	1455
UniProtKB:A0A8M9Q8I6 InterPro	1471
UniProtKB:A0A8M9QML0 InterPro	1472
UniProtKB:A0A8M9PWG1 InterPro	1417
UniProtKB:B6EUL5 InterPro	419
UniProtKB:A0A8M3AYC2 InterPro	1494

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nrxn1a-201 (1) Ensembl	Ensembl	1,425 nt	Select Tool
mRNA	nrxn1a-202 (1) Ensembl	Ensembl	3,069 nt	Select Tool
mRNA	nrxn1a-203 (1) Ensembl	Ensembl	9,670 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-204 (1) Ensembl	Ensembl	7,007 nt	Select Tool
mRNA	nrxn1a-205 (1) Ensembl	Ensembl	6,457 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-207 (1) Ensembl	Ensembl	9,643 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-208 (1) Ensembl	Ensembl	9,682 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-209 (1) Ensembl	Ensembl	9,649 nt	Select Tool ZFIN BLAST
ncRNA	nrxn1a-004 (1) Ensembl	Ensembl	906 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations