Gene

nrxn1a

ID

ZDB-GENE-070206-1

Name

neurexin 1a

Symbol

nrxn1a Nomenclature History

Previous Names

nrxn1aa
nrxn1ab

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Involved in sprouting angiogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Orthologous to human NRXN1 (neurexin 1).

Genome Resources

Note

nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rissone et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrxn1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Pitt-Hopkins-like syndrome 2	Alliance	Pitt-Hopkins-like syndrome 2	614325
		{Schizophrenia, susceptibility to, 17}	614332

Associated With nrxn1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR003585	Neurexin/syndecan/glycophorin C
Domain	IPR027789	Syndecan/Neurexin domain
Family	IPR050372	Neurexin-related cell adhesion and synaptic protein
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	Laminin G domain	Neurexin-related cell adhesion and synaptic protein	Neurexin/syndecan/glycophorin C	Syndecan/Neurexin domain
UniProtKB:A0A2R8QKE7 InterPro	1481
UniProtKB:A1XQX1 InterPro	449
UniProtKB:A0A8M3B4L1 InterPro	1491
UniProtKB:A0A8M3BE54 InterPro	1488
UniProtKB:A0A8M3AYC5 InterPro	1489
UniProtKB:A0A8M3AYD0 InterPro	1454
UniProtKB:A0A8M3B7E0 InterPro	1492
UniProtKB:A0A8M9QIT8 InterPro	1445
UniProtKB:A0A8M3BE57 InterPro	1451
UniProtKB:A0A8M2B276 InterPro	1488
UniProtKB:A0A8M9QED3 InterPro	1475
UniProtKB:A0A8M3B7E5 InterPro	1467
UniProtKB:A0A8M9Q8I0 InterPro	1477
UniProtKB:A0A8M9QIT3 InterPro	1487
UniProtKB:A0A8M3B4L5 InterPro	1464
UniProtKB:A0A8M3B7D6 InterPro	1497
UniProtKB:A1XQX0 InterPro	1491
UniProtKB:A0A8M3B4K7 InterPro	1496
UniProtKB:A0A140TAU1 InterPro	1484
UniProtKB:A0A8M9QML2 InterPro	1414
UniProtKB:A0A8M3AY99 InterPro	1493
UniProtKB:A0A8M3BE52 InterPro	1493
UniProtKB:A0A8M9QIU1 InterPro	1422
UniProtKB:A0A8M9QED6 InterPro	1455
UniProtKB:A0A8M9Q8I6 InterPro	1471
UniProtKB:A0A8M9QML0 InterPro	1472
UniProtKB:A0A8M9PWG1 InterPro	1417
UniProtKB:B6EUL5 InterPro	419
UniProtKB:A0A8M3AYC2 InterPro	1494

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nrxn1a-201 (1) Ensembl	Ensembl	1,425 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-202 (1) Ensembl	Ensembl	3,069 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-203 (1) Ensembl	Ensembl	9,670 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-204 (1) Ensembl	Ensembl	7,007 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-205 (1) Ensembl	Ensembl	6,457 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-207 (1) Ensembl	Ensembl	9,643 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-208 (1) Ensembl	Ensembl	9,682 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-209 (1) Ensembl	Ensembl	9,649 nt	Select Tool ZFIN BLAST
ncRNA	nrxn1a-004 (1) Ensembl	Ensembl	906 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations