Gene
hs2st1a
- ID
- ZDB-GENE-070112-2312
- Name
- heparan sulfate 2-O-sulfotransferase 1a
- Symbol
- hs2st1a Nomenclature History
- Previous Names
-
- hs2st1
- im:7147474
- zgc:158230
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Exhibits heparan sulfate sulfotransferase activity. Involved in epiboly involved in gastrulation with mouth forming second; regulation of canonical Wnt signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; immature eye; otic vesicle; pectoral fin; and segmental plate. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147474 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Cadwalader et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurofacioskeletal syndrome with or without renal agenesis | 619194 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Heparan sulphate 2-O-sulfotransferase | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase |
|---|---|---|---|---|
|
UniProtKB:A1L1P8
|
354 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hs2st1a-201
(1)
|
Ensembl | 5,095 nt |
Interactions and Pathways
No data available
Plasmids
No data available