Gene
traf7
- ID
- ZDB-GENE-070112-2212
- Name
- TNF receptor-associated factor 7
- Symbol
- traf7 Nomenclature History
- Previous Names
-
- im:7149067
- zgc:158391
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including protein polyubiquitination; proteolysis; and regulation of proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenomatoid tumor; hepatocellular carcinoma; and peritoneal mesothelioma. Orthologous to human TRAF7 (TNF receptor associated factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149067 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Mishra-Gorur et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cardiac, facial, and digital anomalies with developmental delay | 618164 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR027370 | Zinc finger, RING-type, eukaryotic |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | G-protein beta WD-40 repeat | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A1L1U9
|
639 |
Interactions and Pathways
No data available
Plasmids
No data available