Gene
pank2
- ID
- ZDB-GENE-070112-1952
- Name
- pantothenate kinase 2
- Symbol
- pank2 Nomenclature History
- Previous Names
-
- zgc:158667 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable pantothenate kinase activity. Acts upstream of or within nervous system development and vasculature development. Predicted to be active in cytosol and nucleus. Is expressed in axial blood vessel; caudal vein plexus; central nervous system; and epidermis. Used to study pantothenate kinase-associated neurodegeneration. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pantothenate kinase-associated neurodegeneration | Alliance | Neurodegeneration with brain iron accumulation 1 | 234200 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| pantothenate kinase-associated neurodegeneration | AB + MO1-pank2 | standard conditions | Zizioli et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ATPase, nucleotide binding domain | Type II pantothenate kinase |
|---|---|---|---|
|
UniProtKB:A0A8M2B2L8
|
243 | ||
|
UniProtKB:A0A8M2B3B3
|
355 | ||
|
UniProtKB:B8A4W8
|
437 |
Interactions and Pathways
No data available
Plasmids
No data available