Gene
cdt1
- ID
- ZDB-GENE-070111-1
- Name
- chromatin licensing and DNA replication factor 1
- Symbol
- cdt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and DNA polymerase binding activity. Involved in mitotic cell cycle. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Is expressed in several structures, including immature eye; mesoderm; proliferative region; pronephric duct; and somite. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158083 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 4 | Alliance | Meier-Gorlin syndrome 4 | 613804 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014939 | CDT1 Geminin-binding domain-like |
| Domain | IPR032054 | DNA replication factor Cdt1, C-terminal |
| Family | IPR045173 | DNA replication factor Cdt1 |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR038090 | DNA replication factor Cdt1, C-terminal WH domain superfamily |
Domain Details Per Protein
| Protein | Length | CDT1 Geminin-binding domain-like | DNA replication factor Cdt1 | DNA replication factor Cdt1, C-terminal | DNA replication factor Cdt1, C-terminal WH domain superfamily | Winged helix DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZJ1
|
628 | |||||
|
UniProtKB:E7F2R5
|
678 |
Interactions and Pathways
No data available
Plasmids
No data available