Gene

cyp21a2

ID

ZDB-GENE-070103-6

Name

cytochrome P450, family 21, subfamily A, polypeptide 2

Symbol

cyp21a2 Nomenclature History

Previous Names

cyp21a1 (1)
si:ch1073-443n13.1
si:ch211-257p13.4

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in glucocorticoid biosynthetic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Is expressed in brain; head; and renal system. Orthologous to human CYP21A2 (cytochrome P450 family 21 subfamily A member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Eachus et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp21a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital adrenal hyperplasia	Alliance	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	201910
congenital adrenal hyperplasia	Alliance	Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency	201910

Associated With cyp21a2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Length	Cytochrome P450	Cytochrome P450, conserved site	Cytochrome P450, E-class, group I	Cytochrome P450 superfamily
UniProtKB:A0A8M9NZM6 InterPro	522

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cyp21a2-201 (1) Ensembl	Ensembl	1,828 nt	Select Tool
mRNA	cyp21a2-202 (1) Ensembl	Ensembl	3,078 nt	Select Tool ZFIN BLAST
mRNA	cyp21a2-203 (1) Ensembl	Ensembl	3,177 nt	Select Tool ZFIN BLAST
mRNA	cyp21a2-204 (1) Ensembl	Ensembl	2,991 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations