Gene
clrn2
- ID
- ZDB-GENE-061207-64
- Name
- clarin 2
- Symbol
- clrn2 Nomenclature History
- Previous Names
-
- si:dkey-245p14.5
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Involved in auditory receptor cell stereocilium organization and sensory perception of sound. Acts upstream of or within auditory receptor cell morphogenesis. Located in cell hair. Is expressed in several structures, including gill; inner ear; integument; notochord; and testis. Used to study autosomal recessive nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human CLRN2 (clarin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Vona et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Vona et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Deafness, autosomal recessive 117 | 619174 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness | WT + CRISPR3-clrn2 + CRISPR4-clrn2 + CRISPR5-clrn2 + CRISPR6-clrn2 + CRISPR7-clrn2 | standard conditions | Vona et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026748 | Clarin |
Domain Details Per Protein
| Protein | Length | Clarin |
|---|---|---|
|
UniProtKB:B8A5K7
|
233 |
Interactions and Pathways
No data available
Plasmids
No data available