Gene

shank2b

ID

ZDB-GENE-061207-58

Name

SH3 and multiple ankyrin repeat domains 2b

Symbol

shank2b Nomenclature History

Previous Names

shank2
si:dkey-221m4.1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have GKAP/Homer scaffold activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of synaptic transmission; and regulation of AMPA receptor activity. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Wang et al., 2023

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Wang et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With shank2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Autism susceptibility 17}	613436

Associated With shank2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR032425	Talin, N-terminal F0 domain
Family	IPR051569	SH3 and multiple ankyrin repeat domains protein
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	PDZ domain	PDZ superfamily	SH3 and multiple ankyrin repeat domains protein	SH3 domain	SH3-like domain superfamily	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily	Talin, N-terminal F0 domain
UniProtKB:A0A8M3B750 InterPro	1440
UniProtKB:A0A8M9P6G4 InterPro	1810
UniProtKB:A0A8M3AP18 InterPro	1803
UniProtKB:A0A8M3APN7 InterPro	1235
UniProtKB:A2AV32 InterPro	1800