Gene
tyrobp
- ID
- ZDB-GENE-061130-2
- Name
- transmembrane immune signaling adaptor TYROBP
- Symbol
- tyrobp Nomenclature History
- Previous Names
-
- dap12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have kinase activity. Involved in phosphatidylinositol 3-kinase signaling. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Is expressed in liver; lymphocyte; and pleuroperitoneal region. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Nasu-Hakola disease | Alliance | Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 | 221770 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026200 | TYRO protein tyrosine kinase-binding protein |
Domain Details Per Protein
| Protein | Length | TYRO protein tyrosine kinase-binding protein |
|---|---|---|
|
UniProtKB:F1QN44
|
115 | |
|
UniProtKB:A0A8M3B1L0
|
173 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tyrobp-201
(1)
|
Ensembl | 796 nt |
Interactions and Pathways
No data available
Plasmids
No data available