Gene

aldh1a3

ID

ZDB-GENE-061128-2

Name

aldehyde dehydrogenase 1 family, member A3

Symbol

aldh1a3 Nomenclature History

Previous Names

Raldh3 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Is expressed in several structures, including brain; immature eye; otic vesicle; pleuroperitoneal region; and sensory system. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

26 figures from 22 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aldh1a3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
isolated microphthalmia 8	Alliance	Microphthalmia, isolated 8	615113

Associated With aldh1a3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016160	Aldehyde dehydrogenase, cysteine active site
Conserved_site	IPR029510	Aldehyde dehydrogenase, glutamic acid active site
Domain	IPR015590	Aldehyde dehydrogenase domain
Homologous_superfamily	IPR016161	Aldehyde/histidinol dehydrogenase
Homologous_superfamily	IPR016162	Aldehyde dehydrogenase, N-terminal
Homologous_superfamily	IPR016163	Aldehyde dehydrogenase, C-terminal