Gene

ap1b1

ID

ZDB-GENE-061025-1

Name

adaptor related protein complex 1 subunit beta 1

Symbol

ap1b1 Nomenclature History

Previous Names

skb (1)
fa11e04
si:ch211-149d1.1
skylab (1)
wu:fa11e04

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have clathrin binding activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception; hair cell differentiation; and sensory organ development. Predicted to localize to clathrin adaptor complex. Is expressed in brain; eye; female organism; inner ear; and otic vesicle. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ap1b1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Keratitis-ichthyosis-deafness syndrome, autosomal recessive	242150

Associated With ap1b1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
Domain	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
Domain	IPR015151	Beta-adaptin appendage, C-terminal subdomain
Family	IPR016342	AP-1/2/4 complex subunit beta
Family	IPR026739	AP complex subunit beta
Homologous_superfamily	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR012295	TBP domain superfamily
Homologous_superfamily	IPR013037	Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
Homologous_superfamily	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR000225	Armadillo

Domain Details Per Protein

Protein	Length	AP-1/2/4 complex subunit beta	AP complex subunit beta	Armadillo	Armadillo-like helical	Armadillo-type fold	Beta-adaptin appendage, C-terminal subdomain	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Coatomer/calthrin adaptor appendage, C-terminal subdomain	TBP domain superfamily
UniProtKB:A0A8M3AZG4 InterPro	995
UniProtKB:A0A8M2BCC8 InterPro	966
UniProtKB:A5PMS9 InterPro	947
UniProtKB:A0A8M2BCH0 InterPro	963
UniProtKB:A0A8M2BCE3 InterPro	992
UniProtKB:A0A8M3B9I1 InterPro	979
UniProtKB:A0A8M9PKD8 InterPro	973
UniProtKB:A0A8M3AS47 InterPro	988

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ap1b1-201 (1) Ensembl	Ensembl	4,387 nt	Select Tool
mRNA	ap1b1-202 (1) Ensembl	Ensembl	654 nt	Select Tool
mRNA	ap1b1-203 (1) Ensembl	Ensembl	3,135 nt	Select Tool ZFIN BLAST
mRNA	ap1b1-204 (1) Ensembl	Ensembl	3,063 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations