Gene

ces2a

ID
ZDB-GENE-061013-99
Name
carboxylesterase 2a
Symbol
ces2a Nomenclature History
Previous Names
  • ces2 (1)
  • cbe (1)
  • im:6908784
  • si:dkey-38l12.2
  • zgc:153863
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable carboxylic ester hydrolase activity. Is expressed in liver; pectoral fin; pleuroperitoneal region; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES2 (carboxylesterase 2).
Genome Resources
Note
Some publications were mistakingly attributed to "ces2" before it was determined that there are 2 genes, ces2a and ces2b in zebrafish. The attributions have been corrected. IMPORTANT: qPCR primers for ces2 from Zhao et al. (2010) do not BLAST to any known ces2 sequences
Comparative Information
Expression
All Expression Data
11 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ces2a Human Ortholog
No data available
Associated With ces2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019826 Carboxylesterase type B, active site
Conserved_site IPR019819 Carboxylesterase type B, conserved site
Domain IPR002018 Carboxylesterase, type B
Family IPR050309 Type-B Carboxylesterase/Lipase
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Additional Resources Length Alpha/Beta hydrolase fold Carboxylesterase, type B Carboxylesterase type B, active site Carboxylesterase type B, conserved site Type-B Carboxylesterase/Lipase
UniProtKB:F1R9X5 InterPro 556
UniProtKB:A0A8M9PPJ2 InterPro 554
UniProtKB:A0A8M9PFI2 InterPro 419
UniProtKB:Q08BF1 InterPro 555
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
aberrant processed transcript ces2-202 (1) Ensembl 821 nt
mRNA ces2-201 (1) Ensembl 1,779 nt
mRNA ces2-203 (1) Ensembl 419 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations