Gene

smg1

ID

ZDB-GENE-061013-767

Name

SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Symbol

smg1 Nomenclature History

Previous Names

zgc:152973

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in nucleus. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smg1 Human Ortholog

No data available

Associated With smg1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003152	FATC domain
Domain	IPR014009	PIK-related kinase
Domain	IPR035175	Serine/threonine-protein kinase SMG1, N-terminal
Domain	IPR039414	SMG1, PIKK catalytic domain
Family	IPR031559	Serine/threonine-protein kinase SMG1
Family	IPR050517	DNA Damage Response and Repair Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	DNA Damage Response and Repair Kinase	FATC domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	PIK-related kinase	Protein kinase-like domain superfamily	Serine/threonine-protein kinase SMG1	Serine/threonine-protein kinase SMG1, N-terminal	SMG1, PIKK catalytic domain
UniProtKB:A0A8I7UD82 InterPro
UniProtKB:F1QLT4 InterPro	3635
UniProtKB:C5J7W8 InterPro	3640
UniProtKB:A0A2R8QK29 InterPro	3644
UniProtKB:A0A8M3AQW2 InterPro	3641
UniProtKB:A0A8M3B0Y6 InterPro	3640