Gene
foxo1a
- ID
- ZDB-GENE-061013-59
- Name
- forkhead box O1 a
- Symbol
- foxo1a Nomenclature History
- Previous Names
-
- foxo1
- foxo1a.1 (1)
- zgc:153388
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in lymph vessel development; smooth muscle cell proliferation; and smooth muscle tissue development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Is expressed in digestive system; head mesenchyme; pericardial region; and pharyngeal arch. Orthologous to human FOXO1 (forkhead box O1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gays et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma, alveolar | 268220 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR032067 | FOXO protein, transactivation domain |
| Domain | IPR032068 | FOXO protein, KIX-binding domain |
| Domain | IPR047408 | Forkhead box protein O1, forkhead domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead box protein O1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXO protein, KIX-binding domain | FOXO protein, transactivation domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A3RK74
|
652 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxo1a-201
(1)
|
Ensembl | 5,915 nt | ||
| mRNA |
foxo1a-202
(1)
|
Ensembl | 1,959 nt | ||
| mRNA |
foxo1a-203
(1)
|
Ensembl | 1,146 nt |
Interactions and Pathways
No data available
Plasmids
No data available