Gene
tfam
- ID
- ZDB-GENE-061013-552
- Name
- transcription factor A, mitochondrial
- Symbol
- tfam Nomenclature History
- Previous Names
-
- zgc:153358
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity, bending and transcription cis-regulatory region binding activity. Acts upstream of or within regulation of female gonad development and regulation of mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid and nucleus. Is expressed in several structures, including digestive system; gonad; muscle; pericardial region; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Ullah et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 15 | Alliance | ?Mitochondrial DNA depletion syndrome 15 (hepatocerebral type) | 617156 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) |
|---|---|---|---|---|
|
UniProtKB:Q08BL2
|
277 |
Interactions and Pathways
No data available
Plasmids
No data available