Gene
mcu
- ID
- ZDB-GENE-061013-24
- Name
- mitochondrial calcium uniporter
- Symbol
- mcu Nomenclature History
- Previous Names
-
- ccdc109a
- wu:fi24a01
- zgc:153607 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits identical protein binding activity. Involved in several processes, including actin filament organization; calcium import into the mitochondrion; and convergent extension involved in gastrulation. Predicted to localize to integral component of mitochondrial inner membrane and uniplex complex. Is expressed in brain; heart; heart tube; and visceral fat. Orthologous to human MCU (mitochondrial calcium uniporter).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cardiomyopathy | mcula2434/la2434 | standard conditions | Langenbacher et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium uniporter protein, C-terminal | MCU family |
|---|---|---|---|
|
UniProtKB:K0A5D6
|
376 | ||
|
UniProtKB:Q08BI9
|
376 |
Interactions and Pathways
No data available
Plasmids