Gene

zgc:152891

ID

ZDB-GENE-061013-229

Name

zgc:152891

Symbol

zgc:152891 Nomenclature History

Previous Names

alox12b (1)
ALOX4b (1)
wu:fi89d03
zgc:153926

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have iron ion binding activity and linoleate 13S-lipoxygenase activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 2; and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type); ALOX15B (arachidonate 15-lipoxygenase type B); and ALOXE3 (arachidonate lipoxygenase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zgc:152891 Human Ortholog

No data available

Associated With zgc:152891 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily

Domain Details Per Protein

Protein	Length	Lipoxigenase, C-terminal domain superfamily	Lipoxygenase	Lipoxygenase, conserved site	Lipoxygenase, C-terminal	Lipoxygenase, mammalian	PLAT/LH2 domain	PLAT/LH2 domain superfamily
UniProtKB:F1QKM3 InterPro	663
UniProtKB:B2GSC9 InterPro	611

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zgc:152891-201 (1) Ensembl	Ensembl	2,204 nt	Select Tool
mRNA	zgc:152891-202 (1) Ensembl	Ensembl	4,997 nt	Select Tool ZFIN BLAST
mRNA	zgc:152891-203 (1) Ensembl	Ensembl	1,862 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations