Gene

foxp1a

ID

ZDB-GENE-060929-624

Name

forkhead box P1a

Symbol

foxp1a Nomenclature History

Previous Names

im:7146611
wu:fb97f01
zgc:154010

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; peritonitis; and schizophrenia. Is expressed in ventral wall of dorsal aorta. Orthologous to human FOXP1 (forkhead box P1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxp1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual disability-severe speech delay-mild dysmorphism syndrome	Alliance	Intellectual developmental disorder with language impairment with or without autistic features	613670

Associated With foxp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR032354	FOXP, coiled-coil domain
Domain	IPR047412	Forkhead box protein P1/P2, forkhead domain
Family	IPR050998	Forkhead box protein P
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead box protein P	Forkhead box protein P1/P2, forkhead domain	Fork head domain	Fork head domain conserved site 2	FOXP, coiled-coil domain	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:F1Q4T2 InterPro	637
UniProtKB:A0A2R8Q1R5 InterPro	638
UniProtKB:A0A8N7XJ37 InterPro	433
UniProtKB:A0A8M9P554 InterPro	605
UniProtKB:A0A8M9PF34 InterPro	604
UniProtKB:A0A8M2B938 InterPro	553

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	foxp1a-201 (1) Ensembl	Ensembl	1,449 nt	Select Tool ZFIN BLAST
mRNA	foxp1a-202 (1) Ensembl	Ensembl	3,042 nt	Select Tool ZFIN BLAST
mRNA	foxp1a-204 (1) Ensembl	Ensembl	558 nt	Select Tool ZFIN BLAST
mRNA	foxp1a-205 (1) Ensembl	Ensembl	1,305 nt	Select Tool ZFIN BLAST
mRNA	foxp1a-206 (1) Ensembl	Ensembl	6,526 nt	Select Tool ZFIN BLAST
ncRNA	foxp1a-003 (1) Ensembl	Ensembl	470 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations