Gene
foxp1a
- ID
- ZDB-GENE-060929-624
- Name
- forkhead box P1a
- Symbol
- foxp1a Nomenclature History
- Previous Names
-
- im:7146611
- wu:fb97f01
- zgc:154010
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; dorsal telencephalon; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| intellectual disability-severe speech delay-mild dysmorphism syndrome | Alliance | Intellectual developmental disorder with language impairment with or without autistic features | 613670 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR032354 | FOXP, coiled-coil domain |
| Domain | IPR047412 | Forkhead box protein P1/P2, forkhead domain |
| Family | IPR050998 | Forkhead box protein P |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein P | Forkhead box protein P1/P2, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXP, coiled-coil domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q4T2 | InterPro | 637 | |||||||
| UniProtKB:A0A2R8Q1R5 | InterPro | 638 | |||||||
| UniProtKB:A0A8N7XJ37 | InterPro | 433 | |||||||
| UniProtKB:A0A8M9P554 | InterPro | 605 | |||||||
| UniProtKB:A0A8M9PF34 | InterPro | 604 | |||||||
| UniProtKB:A0A8M2B938 | InterPro | 553 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxp1a-201
(1)
|
Ensembl | 1,449 nt | ||
| mRNA |
foxp1a-202
(1)
|
Ensembl | 3,042 nt | ||
| mRNA |
foxp1a-204
(1)
|
Ensembl | 558 nt | ||
| mRNA |
foxp1a-205
(1)
|
Ensembl | 1,305 nt | ||
| mRNA |
foxp1a-206
(1)
|
Ensembl | 6,526 nt | ||
| ncRNA |
foxp1a-003
(1)
|
Ensembl | 470 nt |
Interactions and Pathways
No data available
Plasmids
No data available