Gene
dync1i2a
- ID
- ZDB-GENE-060929-1086
- Name
- dynein, cytoplasmic 1, intermediate chain 2a
- Symbol
- dync1i2a Nomenclature History
- Previous Names
-
- dync1i2
- im:7147021
- zgc:153318
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to contribute to plus-end-directed microtubule motor activity. Acts upstream of or within mitotic spindle organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of cytoplasmic dynein complex. Used to study primary autosomal recessive microcephaly. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147021 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ansar et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly and structural brain anomalies | 618492 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR025956 | Cytoplasmic dynein 1 intermediate chain 1/2 |
| Family | IPR050687 | Dynein Intermediate Chain |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Length | Cytoplasmic dynein 1 intermediate chain 1/2 | Dynein Intermediate Chain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q08CA8
|
471 | |||||
|
UniProtKB:A0A8M6Z827
|
626 | |||||
|
UniProtKB:A0A286YAG4
|
608 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dync1i2a-201
(1)
|
Ensembl | 5,406 nt | ||
| mRNA |
dync1i2a-202
(1)
|
Ensembl | 1,038 nt | ||
| mRNA |
dync1i2a-203
(1)
|
Ensembl | 984 nt | ||
| mRNA |
dync1i2a-204
(1)
|
Ensembl | 1,912 nt | ||
| mRNA |
dync1i2a-205
(1)
|
Ensembl | 4,307 nt | ||
| mRNA |
dync1i2a-206
(1)
|
Ensembl | 5,352 nt | ||
| mRNA | si:ch1073-276n13.1-001 (1) | 1,038 nt |
Interactions and Pathways
No data available
Plasmids
No data available