Gene

scn12aa

ID

ZDB-GENE-060908-2

Name

sodium channel, voltage gated, type XII, alpha a

Symbol

scn12aa Nomenclature History

Previous Names

scn5Laa (1)
zscn6 (1)
zmp:0000001002

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have voltage-gated sodium channel activity. Involved in heart looping and regulation of heart contraction. Predicted to localize to voltage-gated sodium channel complex. Is expressed in nervous system and pericardial region.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Chopra et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scn12aa Human Ortholog

No data available

Associated With scn12aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR005821	Ion transport domain
Domain	IPR010526	Sodium ion transport-associated domain
Domain	IPR024583	Voltage-gated Na+ ion channel, cytoplasmic domain
Domain	IPR044564	Voltage-gated sodium channel alpha subunit, inactivation gate
Family	IPR001696	Voltage gated sodium channel, alpha subunit
Family	IPR043203	Voltage-gated cation channel calcium and sodium
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily